The 6AU6 amps I have found all drive smaller tubes, mostly 6AQ5 (various Univox). Without going into detail, I think Sven may be right. You also want to be able to drive the EL34(s), and if a single 6AU6 is used to drive a 6AQ5, I'm willing to bet it won't swing enough voltage to drive an EL34 as hard as you would want in a modern amp.
You might want to look at EF86-based amps and see how they are designed, substituting a 6AU6 shouldn't be a big deal
steven